Depends on your machine spec. E.g. If you have a lot of tabs open in Chrome it's quite heavy on memory. So on my little underconfigured Atom laptop with next to no memory, more than about 3 tabs virtually stops the machine. My desktop carries on as if nothing is happening with more than 20 (which is my number of start-up tabs).
I'd agree that the cache has rarely caused me a problem.
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