Yeah i was mentioning disk use earlier. However if it's in the middle of a scan and you reboot it, it may well be OK until next time it does the scan. IMO it's best to leave it for many many hours and see if it completes. If not then start an investigation.
Might be worth clearing your internet cache as there may be something inadvertently downloaded which could be trying to block Defender running properly, or causing it other grief.
(Some recent Windows updates take many hours even on a well specc'd PC, and scanning and decompressing etc would all be stressful on the disk without much discernible outcome for many hours. Keep interrupting it and it will just keep restarting...)
Doing a disk check is also a good idea, nothing to lose.
Also I suppose worth checking that the disk isn't nearing being full, as that would cut down space available for swapfiles.
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