Normally I would agree with you, Smokie, and just ignore it. But in this instance the behaviour on Reply bothers me.
If Mr. X sent Ambo an email, which he received, but Ambo using Reply caused the legit email to be replaced with a Spam email is unusual and somewhat more concerning. Unusual to the point where I've never encountered it, though that is not the be all and end all.
Assuming we're not missing something it is almost certain that one of the two machines has active malware which needs to be found and removed.
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Spam 
Spam 